浠婂ぉ鏄細

瀹為獙瀹よ祫璁綉

Nature :鐑熼厭瀹冲閮芥湁鍟ワ紵鍘熸潵椋熺鐧屼篃璧栧畠锛佸疄閿ょ儫閰掍负鐧岀棁绐佸彉鐨勯噸瑕佹帹鎵嬶紒

瀹為獙瀹よ祫璁綉鏃堕棿:2019-01-06 鐐瑰嚮: 娆?/span> 鐧惧害鎼滅储

銆愬璇汇€?/strong>椋熺鐧屾槸甯歌鐨勬秷鍖栭亾鑲跨槫锛屽叏涓栫晫姣忓勾绾︽湁30涓囦汉姝讳簬椋熺鐧屻€傜劧鑰岋紝鐩墠椋熺鐧屽彂鐢熷拰鍙戝睍鐨勬満鍒跺皻涓嶆槑浜嗭紝缂轰箯鐗瑰紓鎬х殑鍒嗗瓙闈剁偣鍜屾湁鏁堢殑娌荤枟鑽墿锛屽洜鑰屾垚涓轰簡灞呮皯鍋ュ悍鐨勪竴澶у▉鑳併€傛垜浠櫘閬嶈涓轰笉鑹敓娲讳範鎯槸椋熺鐧岀殑閲嶈鎺ㄦ墜锛屼絾鏄櫎浜嗘粴鐑鐗╁椋熺鐨勬崯浼わ紝鍏朵粬鐢熸椿涔犳儻瀵归绠$檶鐨勫奖鍝嶆垜......
TAG鏍囩锛?Nature 椋熺鐧?/a> 鐑熼厭瀹冲 鐑熼厭 鐧岀棁绐佸彉

椋熺鐧屾槸甯歌鐨勬秷鍖栭亾鑲跨槫锛屽叏涓栫晫姣忓勾绾︽湁30涓囦汉姝讳簬椋熺鐧屻€傜劧鑰岋紝鐩墠椋熺鐧屽彂鐢熷拰鍙戝睍鐨勬満鍒跺皻涓嶆槑浜嗭紝缂轰箯鐗瑰紓鎬х殑鍒嗗瓙闈剁偣鍜屾湁鏁堢殑娌荤枟鑽墿锛屽洜鑰屾垚涓轰簡灞呮皯鍋ュ悍鐨勪竴澶у▉鑳併€傛垜浠櫘閬嶈涓轰笉鑹敓娲讳範鎯槸椋熺鐧岀殑閲嶈鎺ㄦ墜锛屼絾鏄櫎浜嗘粴鐑鐗╁椋熺鐨勬崯浼わ紝鍏朵粬鐢熸椿涔犳儻瀵归绠$檶鐨勫奖鍝嶆垜浠煡涔嬬敋灏戙€傝繎鏃ワ紝鏃ユ湰浜兘澶у鐨勭爺绌朵汉鍛樺湪钁楀悕瀛︽湳鏈熷垔銆奛ature銆嬩笂鍙戣〃鐨勬枃绔犳寚鍑猴紝浠ョ儫閰掍负浼村彲鍔犻€熻鍙戝绉嶉绠$檶鎭舵€х獊鍙橈紒浠栦滑寮鸿皟锛岀儫閰掓鏄绠$檶鐨勯噸瑕佹帹鎵嬩箣涓€锛?/p>

Nature :鐑熼厭瀹冲閮芥湁鍟ワ紵鍘熸潵椋熺鐧屼篃璧栧畠锛佸疄閿ょ儫閰掍负鐧岀棁绐佸彉鐨勯噸瑕佹帹鎵嬶紒

“涓浗鐗硅壊鐧岀棁”

   

鎴戝浗鏄绠$檶楂樺彂鍥藉锛屽彂鐥呯巼涓?0-30/鍗佷竾浜猴紝鐥呬緥鏁板崰鍏ㄧ悆50%锛屽叾涓?0%鐥呯悊绫诲瀷涓洪碁鐧屻€傚湪鍏ㄥ浗鑼冨洿鍐咃紝姣忓勾骞冲潎鐥呮绾?5涓囦汉銆傝€屽湪缇庡浗锛?strong>椋熺鐧屽彂鐥呯巼浣庯紝绾︿负5/鍗佷竾浜猴紝涓旂梾鐞嗙被鍨嬩互鑵虹檶涓轰富锛屽崰涓€鍗婁互涓娿€?/strong>

鏈夌爺绌舵寚鍑猴紝鎴戝浗椋熺槌炵檶鐨勫垎瀛愮壒寰佷笌瑗挎柟鎮h€呮湁鏄庢樉鐨勫樊寮傦紝鑰屼笖寮傝川鎬ч珮锛岄┍鍔ㄥ洜绱犲鏉傦紝杩欎篃鎭版伆鏄洰鍓嶉绠¢碁鐧屾不鐤楄繎20浣欏勾鍋滄粸涓嶅墠鐨勭棁缁撴墍鍦紝浣夸箣鎴愪负浜?ldquo;涓浗鐗硅壊鐧岀棁”銆?/p>

浣嗘槸锛?ldquo;涓浗鐗硅壊”鏄惁浠呴檺浜庡垎瀛愮壒寰佺殑宸紓鍛紵涓嶆槸鐨勶紝涓嶈壇鐢熸椿涔犳儻鍚屾牱鏄垜鍥介绠$檶楂樺彂鐨勫箷鍚庨粦鎵嬨€?ldquo;瓒佺儹鍚?rdquo;宸茶璇佸疄璺熼绠$檶楂樺彂鑴变笉浜嗗叧绯汇€?strong>闀挎湡椋熺敤杩囩儷鐨勯鐗╋紝浼氬鑷撮绠$矘鑶滀笉鏂殑鍙楀埌杩囩儹鐨勫埡婵€锛屼細寮曡捣瀹冨嚭鐜颁笉鏂殑澧炲帤銆?/strong>

澧炲帤鐨勭矘鑶滃浜庣儹鍒烘縺浼氬彉寰楄秺鏉ヨ秺涓嶆晱鎰燂紝瀵艰嚧椋熺鍙樺緱瓒婃潵瓒婁笉鎬曠儹锛屽姝や竴鐩寸殑杩涜鎭舵€у惊鐜紝浼氬鑷村嚭鐜颁箙娌讳笉鎰堢殑椋熺鐐庯紝杩欑椋熺鐐庡緢鍙兘浼氬彂灞曟垚涓虹檶鐥囥€傞偅涔堬紝涓?ldquo;瓒佺儹鍚?rdquo;鍚屼负涓浗浜洪噸瑕佺敓娲讳範鎯殑“鏉Д浜ら敊”“鐑熺啅鐏噹”涓庨绠$檶鐨勫彂鐢熸槸鍚︽湁鍏崇郴鍛紵

鐑熼厭—椋熺鐧岄噸瑕佹帹鎵?/strong>

鎴戜滑鐭ラ亾锛孌NA浼氶殢鐫€缁嗚優鍒嗚澶嶅埗锛岃€屽鍒惰繃绋嬫棤娉曞仛鍒版鏃犻敊婕忋€傞殢鐫€鏃堕棿鐨勬帹绉伙紝DNA閲岀殑绐佸彉涔熼€愭绱Н銆傚ぇ閮ㄥ垎绐佸彉瀵圭粏鑳炶涓烘病鏈夊お澶氬奖鍝嶏紝浣?strong>褰撲竴浜涘叧閿熀鍥犲彂鐢熺獊鍙樻椂锛屼細缁欎簣缁嗚優鎭舵€х敓闀跨殑鑳藉姏锛岃€屼笖杩欑鑳藉姏浼氱Н灏戞垚澶氥€?/strong>

褰撹繖绉嶈兘鍔涘交搴曞け鎺э紝缁嗚優鐢熼暱灏变笉鍐嶅彈鏈轰綋璋冩帶锛屾垚涓轰簡鏃犺妭鍒剁敓闀跨殑鐧岀粏鑳炪€備篃灏辨槸璇达紝鍗充娇姝e父鎯呭喌涓嬶紝鎴戜滑鐨勭粏鑳炰篃瀛樺湪涓€浜涘熀鍥犵獊鍙橈紝杩欎簺绐佸彉鐨?ldquo;澶辨帶”姝f槸鐧岀棁鐨勫彂鐥呮牴婧愶紝鑰?strong>鐑熼厭姝f槸椋熺缁嗚優绐佸彉閫冭劚鏋烽攣锛屽鑷寸粏鑳炶倖鎰忕敓闀跨殑閲嶈鍘熷洜銆?/strong>

Nature :鐑熼厭瀹冲閮芥湁鍟ワ紵鍘熸潵椋熺鐧屼篃璧栧畠锛佸疄閿ょ儫閰掍负鐧岀棁绐佸彉鐨勯噸瑕佹帹鎵嬶紒

閫愭棩绱Н鐨勪綋缁嗚優绐佸彉

鐮旂┒浜哄憳鍒嗘瀽浜?39鍚嶅彈璇曡€呯殑椋熺涓婄毊缁勭粐鏍锋湰锛岃褰曚簡瀹為獙鍙備笌鑰呯殑楗厭鍚哥儫鍙层€備粬浠彂鐜伴暱鏈熸娊鐑熷枬閰掔殑鍙楄瘯鑰呮槸椋熺槌炵姸鐧岀殑楂橀闄╀釜浣撱€?strong>杩欎簺浜虹殑缁勭粐涓紝鏃犺椋熺涓婄毊缁嗚優鏄惁鍋ュ悍锛岀獊鍙樼殑鍚噺閮芥樉钁楀鍔狅紝鍚屾椂绐佸彉鐨勭疮绉€熷害鏄捐憲鍔犲揩銆?/strong>

Nature :鐑熼厭瀹冲閮芥湁鍟ワ紵鍘熸潵椋熺鐧屼篃璧栧畠锛佸疄閿ょ儫閰掍负鐧岀棁绐佸彉鐨勯噸瑕佹帹鎵嬶紒

闀挎湡鎶界儫鍠濋厭鐨勫彈璇曡€呯殑椹卞姩绐佸彉

鍦ㄥ缁勭粐鏍锋湰杩涜鍩哄洜妫€娴嬪悗锛岀爺绌朵汉鍛樺湪闀挎湡鎶界儫鍠濋厭鐨勫彈璇曡€呯殑缁勭粐涓彂鐜颁簡寰堝“鐔熶汉”锛屽寘鎷瑾変负涓浗椋熺鐧屾爣蹇楁€х獊鍙樼殑TP53銆丯FE2L2銆丒P300绐佸彉锛屽挨鍏舵槸NFE2L2鍩哄洜鐨勮儦绯荤獊鍙樻樉钁楅珮浜庡叾浠栧彈璇曡€咃紝鑰?strong>NFE2L2宸茶璇佸疄鏄粏鑳炵殑姘у寲鎹熶激椋庨櫓澧為珮杩涜€屽鑷撮绠$檶椋庨櫓鍗囬珮鐨勭姜榄佺ジ棣栦箣涓€銆?/strong>

姝ゅ杩樻湁鍙埡婵€缁嗚優鍒嗚鐨凬OTCH1绐佸彉銆佹姂鍒剁粏鑳炲噵浜$殑PPM1D绐佸彉灞傚嚭涓嶇┓锛屾崲瑷€涔嬶紝涓庣儫閰掍负浼嶈鏈轰綋鐨勬姂鐧岃兘鍔涙瀬澶х▼搴﹀噺寮便€佹偅鐧岄闄╁ぇ澶у鍔犮€?/strong>

鐝嶇埍鐢熷懡锛岃繙绂荤儫閰?/strong>

闅忕潃骞撮緞鐨勫闀匡紝缁嗚優绐佸彉鐨勭疮绉槸闅句互閬垮厤鐨勮繘绋嬶紝鎴戜滑鑳藉仛鐨勫彧鏈変笉璁╄繖浜涚獊鍙樺交搴曞け鎺э紝鑰屾渶濂界殑鏂瑰紡灏辨槸灏藉揩绾犳涓嶈壇鐨勭敓娲讳範鎯紝灏ゅ叾鏄?ldquo;瓒佺儹鍚?rdquo;鍜岀儫閰掍笉鏂繖绉嶆槑鏄惧▉鑳佹満浣撳仴搴风殑涔犳儻銆傜弽鐖辩敓鍛斤紝璋ㄩ槻椋熺鐧屾暡闂紝浠庝粖澶╁紑濮嬶紝杩滅鐑熼厭锛屾槸鏂板勾缁欒嚜宸辨渶濂界殑绀肩墿銆?/p>

鍙傝€冩枃鐚細

Seishi Ogawa,et al.Age-related remodelling of oesophageal epithelia by mutated cancer drivers.Nature (2019) .

Guo, J. et al. Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population. BMC genomics 19, 538.

Chen, X. X. et al. Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing. Nature communications 8, 524,.

Iñigo Martincorena1, Joanna C. Fowler1, Agnieszka Wabik et al. Somatic mutant clones colonize the human esophagus with age. Science, Published Online: 18 October 2018.

锛堟湰鏂囨潵婧愶細Ruthy 锛?

(璐d换缂栬緫锛氬ぇ鏋?

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