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鑲濊剰鐤剧梾棰嗗煙鐮旂┒杩涘睍姹囨€伙紙绗?8鏈燂級

瀹為獙瀹よ祫璁綉鏃堕棿:2017-08-19 鐐瑰嚮: 娆?/span> 鐧惧害鎼滅储

銆愬璇汇€?/strong>1. Nature瀛愬垔锛氱瀛﹀鍙戠幇鑲濊剰鑴傝川浠h阿鏈哄埗 鑲濊剰鏄硸绫诲拰鑴傜被浠h阿鐨勯噸瑕佷腑鏋€傝倽鍐呬唬璋㈤€斿緞鐢遍珮搴︽椿璺冪殑瀛ゅ効鏍稿彈浣擄紙orphan nuclear receptors锛孫NR锛夎浆褰曠綉缁滄帶鍒躲€?瀛ゅ効鏍稿彈浣撴槸鍙楅厤浣撴縺娲荤殑杞?.....
TAG鏍囩锛?鑽槑搴峰痉 鐤剧梾 杩涘睍姹囨€?/a> 鑲濊剰 棰嗗煙鐮旂┒

1. Nature瀛愬垔锛氱瀛﹀鍙戠幇鑲濊剰鑴傝川浠h阿鏈哄埗

鑲濊剰鏄硸绫诲拰鑴傜被浠h阿鐨勯噸瑕佷腑鏋€傝倽鍐呬唬璋㈤€斿緞鐢遍珮搴︽椿璺冪殑瀛ゅ効鏍稿彈浣擄紙orphan nuclear receptors锛孫NR锛夎浆褰曠綉缁滄帶鍒躲€?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;">瀛ゅ効鏍稿彈浣撴槸鍙楅厤浣撴縺娲荤殑杞綍鍥犲瓙锛屼絾鏄叾閰嶄綋灏氫笉鏄庣‘銆?/strong>鐮旂┒琛ㄦ槑锛岃澶氬鍎挎牳鍙椾綋鑳借皟鑺傝偉鑳栧拰浜屽瀷绯栧翱鐥呯殑钀ュ吇浠h阿銆侽NRs鐨勬垚鍛樹箣涓€锛岃榛勯吀鍙椾綋鐩稿叧鐨勫鍎垮彈浣?alpha;锛坮etinoic acid receptor-related orphan receptor-α锛孯ORα锛夋槸鍚勭鐢熺悊鍔熻兘鐨勯噸瑕佽皟鑺傚洜瀛愩€?/span>

 

 

鑲濊剰鐤剧梾棰嗗煙鐮旂┒杩涘睍姹囨€伙紙绗?8鏈燂級

 

杩戞棩锛岄煩鍥藉瀹剁爺绌舵満鏋勭殑绉戠爺浜哄憳鍚堜綔鍦ㄣ€奛ature Communications銆嬩笂鍙戣〃璁烘枃锛屾樉绀?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;">鑲濊剰RORα鍙備笌璋冭妭鑴傝川浣撳唴骞宠 锛岃繖鏄€氳繃閫嗗悜璋冭妭鑳戒粙瀵艰倽鑴忚剛璐ㄤ唬璋㈢殑杩囨哀鍖栫墿閰朵綋澧炴畺婵€娲诲彈浣?γ锛坧eroxisome proliferators-activated receptor-γ 锛孭PARγ锛夌殑杞綍娲绘€ф潵杈炬垚鐨勩€?/span>

 

鐮旂┒鑰呬娇鐢ㄨ倽鐗瑰紓鎬ORα缂洪櫡锛圧ORαLKO锛夊皬榧犲拰楂樿剛鑲ギ椋熺殑缁撳悎妯″瀷鏉ョ爺绌惰倽鑴忚剛璐ㄤ唬璋㈢殑鏈哄埗銆俁ORαLKO灏忛紶鎺ュ彈楂樿剛鑲ギ椋熷悗浼氬嚭鐜颁弗閲嶇殑浠h阿缂洪櫡锛屽寘鎷倽鑴傝偑鍙樻€э紝鑲ヨ儢鍜岃儼宀涚礌鎶垫姉銆傛暣浣撳熀鍥犵粍鍒嗘瀽鏄剧ず锛?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;">Rorα鐨勮倽鑴忕壒寮傛€х己澶变細瀵艰嚧PPARγ淇″彿浼犲澶辫皟锛屽苟澧炲姞鑲濊剰钁¤悇绯栧拰鑴傝川浠h阿銆?/strong>鐮旂┒浜哄憳杩涗竴姝ュ彂鐜帮紝RORα鑳藉嫙闆嗗苟缁撳悎缁勮泲鐧借劚涔欓叞閰?锛圚DAC3锛夊埌PPARγ鍚姩瀛愶紝浠庤€屾姂鍒禤PARγ鐨勮浆褰曘€傚鏋滅粰RORαLKO灏忛紶鏈嶇敤PPARγ鐨勬嫯鎶楀墏GW9662锛屽氨鑳借揪鍒颁笌姝e父RORα绫讳技鐨勬晥鏋滐紝骞跺ぇ澶ф敼鍠勮繖浜涘皬榧犱綋閲嶅鍔犲拰鑲濊剛鑲彉鎬х殑鐘跺喌銆?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;">杩欎簺鏁版嵁鏄剧ず锛?/strong>鐫€鐪间簬璋冭妭RORα娲绘€х殑娌荤枟绛栫暐鍙兘瀵逛唬璋㈢磰涔辩柧鐥呮湁鐩?/strong>銆?/span>

 

2. Scientific Reports锛氭棩鏈爺绌惰€呴槓鏄嶩BV鎰熸煋鑰呰娓呯敓鐗╂爣璁扮墿鐨勬満鍒?/span>

涔欏瀷鑲濈値鐥呮瘨锛圚BV锛夋劅鏌撴槸鑲濈檶鐨勪富瑕佽鍥犮€侶BV瀵艰嚧鐨勮倽鑴忕値鐥囨槸鐢辫鐥呮瘨鎰熸煋鐨勮倽缁嗚優寮曞彂鐨勫厤鐤弽搴斾粙瀵肩殑銆傚綋HBV鎰熸煋鎴愪汉鏃跺彧浼氬鑷寸煭鏆傜殑鑲濊剰鐤剧梾锛屽苟涓斿湪瓒呰繃95锛呯殑鎴愬勾浜轰腑鐥呮瘨浼氳娓呴櫎銆傝€屽綋HBV鎰熸煋鍒氬嚭鐢熴€佸厤鐤郴缁熻繕涓嶅畬鍠勭殑鏂扮敓鍎挎椂锛?0锛呬互涓婄殑鎮e効浼氭寔缁劅鏌撱€傝繖涓樊寮傛殫绀虹潃HBV闇€瑕侀€冭劚瀹夸富鐨勫厤鐤郴缁熸潵杈惧埌鎸佺画鎰熸煋锛屼絾鍏蜂綋鏂瑰紡骞朵笉鏄庣‘銆?/strong>

 

鑲濊剰鐤剧梾棰嗗煙鐮旂┒杩涘睍姹囨€伙紙绗?8鏈燂級

 

鍚湁澶栨硨浣擄紙exosome锛夌殑鑳炲鍥婃场锛坋xtracellular vesicles, EVs锛夋槸缁嗚優閲婃斁鐨勭撼绫崇骇鐨勫泭娉★紝鍚湁铔嬬櫧璐紝mRNA鍜宮iRNA绛夊悇绉嶇粏鑳炴垚鍒嗐€傛劅鏌撹€呭拰鍋ュ悍浜鸿娓呬腑鐨凟V鐩稿叧miRNA锛圗V-miRNA锛夋湁宸紓锛岃繖绉嶅樊寮傝兘鍙嶆槧鐢熺悊鍜岀梾鐞嗙姸鎬侊紝鐢氳嚦鐤剧梾杩涘睍銆傝繎浜涘勾寮€鍙戝嚭鐨勬晱鎰熺殑琛€娓匛V-miRNA鍒嗘瀽涓烘娴嬬柧鐥呰繘灞曟彁渚涗簡鏈夌敤鐨勭敓鐗╂爣璁拌瘖鏂墜娈碉紝浣嗘槸EV-miRNA鍦℉BV鎰熸煋鑰呬綋鍐呯殑鍔熻兘浠嶇劧寰呴槓鏄?/strong>銆?/span>

 

杩戞棩锛屾棩鏈涓爺绌舵満鏋勭殑绉戠爺浜哄憳璋冩煡浜嗙敱HBV鎰熸煋鎮h€呯殑鑲濈粏鑳炲垎娉岀殑EV-miRNA锛?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;">鍙戠幇杩欎簺EV-miRNA鍙兘闈跺悜鐫€鍚勭被娑夊強鎶楃梾姣掑厤鐤殑缁嗚優鍥犲瓙銆傜爺绌惰€呭彂鐜帮紝鍦℉BV鎰熸煋鐨勮倽缁嗚優涓湁5绉峬iRNA琚笂璋冿紝瀹冧滑鍙兘閽堝浜篒L-21 mRNA鐨?'UTR搴忓垪锛屽苟涓旀湁娼滃姏涓嬭皟浜篢缁嗚優涓殑IL-21 mRNA琛ㄨ揪銆傚凡鐭L-21鏄秹鍙婃姉鐥呮瘨鍏嶇柅鐨勯噸瑕佺粏鑳炲洜瀛愶紝鍥犳锛屼笅璋僆L-21鍙兘鏄疕BV閫冮伩瀹夸富鍏嶇柅绯荤粺鐨勬墜娈典箣涓€銆傝璁烘枃鍙戣〃鍦ㄨ繎鏈熺殑銆奡cientific Reports銆嬩笂銆?/span>

 

3. Cocrystal鍏徃鎱㈡€т笝鑲濇柊鑽复搴?鏈熺粨鏋滆壇濂?/span>

Cocrystal Pharma鍏徃杩戞棩瀹e竷锛屽叾鍦ㄧ爺鏂拌嵂CC-31244鍦ㄥ仴搴峰織鎰胯€呭拰涓欏瀷鑲濈値鐥呮瘨锛圚CV锛夋劅鏌撴偅鑰呬腑杩涜鐨勪复搴?a鏈? 1b鏈熷疄楠屾垚鍔熷畬鎴愩€?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;">CC-31244鏄竴绉嶅彛鏈嶇殑骞胯氨鏈夋晥鐨凬S5B闈炴牳鑻锋姂鍒跺墏锛圢NI锛?/strong>锛岃兘涓庢墍鏈変富瑕丠CV鍩哄洜鍨嬬殑NS5B RNA鑱氬悎閰跺彂鐢熶綔鐢紝瀵规姂鍒禜CV澶嶅埗鍏锋湁寰堥珮鐨勬姉鎬с€?/span>

 

鑲濊剰鐤剧梾棰嗗煙鐮旂┒杩涘睍姹囨€伙紙绗?8鏈燂級

 

杩欓」闅忔満锛屽弻鐩诧紝瀹夋叞鍓傚鐓х殑涓村簥1a / 1b瀹為獙鐮旂┒鏃ㄥ湪璇勪及CC-31244鐨勫崟娆″拰澶氭閫掑鍓傞噺鏁堟灉锛屼互纭畾鍏跺湪HCV鎰熸煋鑰呬腑鐨勫畨鍏ㄦ€с€佽€愬彈鎬с€佽嵂浠e姩鍔涘鍜屾姉鐥呮瘨娲绘€с€傝瘯楠屾暟鎹樉绀猴紝姣忔棩涓€娆C-31244锛?00mg鎴?00mg锛夋垨姣忔棩涓ゆ锛?00mg锛夈€佹寔缁?澶╃殑鐢ㄨ嵂鏂规鍏锋湁鏄捐憲涓旀寔涔呯殑鎶楃梾姣掍綔鐢?/strong>锛岀敤鑽粍骞冲潎HCV鐨凴NA鐥呮瘨閲忔瘮鍩虹嚎闄嶄綆浜嗕笂鍗冨€?/strong>銆傚皢CC-31244涓庡叾浠朒CV鑽墿缁勫悎浣跨敤鏃舵樉绀哄嚭浜嗗姞鎴愭垨鍗忓悓鏁堝簲锛岃繖涓鸿秴鐭枟绋嬮浮灏鹃厭鐤楁硶鎻愪緵浜嗛噸瑕佸弬鑰冦€?/span>

 

Cocrystal鍏徃鍓富甯璆ary L. Wilcox鍗氬+琛ㄧず锛?ldquo;鎴愬姛瀹屾垚涓村簥1a鏈?1b鏈熷疄楠屾槸鍏徃鐨勪竴涓噸瑕侀噷绋嬬锛岄壌浜嶤C-31244琛ㄧ幇鍑烘寔缁殑鎶楃梾姣掓椿鎬у拰鏄捐憲鐨勬姉鐥呮瘨鏁堝姏锛屽苟涓斿湪鍋ュ悍浜哄拰HCV鎰熸煋鑰呬腑閮芥湭鍑虹幇鍓傞噺闄愬埗鎬х殑涓嶈壇鍙嶅簲锛屾垜浠揩鍒囧笇鏈涘敖蹇皢CC-31244鎺ㄥ悜涓村簥2鏈熷疄楠岋紝骞朵笌鍏朵粬鐩存帴浣滅敤鐨勬姉鐥呮瘨鑽浉缁撳悎浣跨敤銆?ldquo;

 

鍙傝€冭祫鏂欙細

[1] RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

[2] Identification of the novel 3′ UTR sequences of human IL-21 mRNA as potential targets of miRNAs

[3] CoCrystal announces positive data from the successful completion of Phase 1a/1b trial of the non-nucleoside polymerase inhibitor CC-31244 for the treatment of chronic Hepatitis C infection

锛堟湰鏂囨潵婧愶細鑽槑搴峰痉 锛?

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