浠婂ぉ鏄細

瀹為獙瀹よ祫璁綉

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐?/h2>

瀹為獙瀹よ祫璁綉鏃堕棿:2019-02-28 鐐瑰嚮: 娆?/span> 鐧惧害鎼滅储

銆愬璇汇€?/strong>鍦?019骞?鏈?7鏃ワ紝鍚屾椂鏈?绡嘚ature鏂囩珷鏄湁涓浗瀛﹁€?鍗庝汉鍙戣〃鐨勶紝鍏蜂綋鐨勬垚鏋滃涓嬮潰鎵€浠嬬粛锛?鍖椾含鐢熷懡缁勫鐮旂┒鎵€璐虹鍒濓紝澶嶆棪澶у闄勫睘涓北鍖婚櫌妯婂槈锛屽浗瀹惰泲鐧借川绉戝涓績閽卞皬绾㈠叡鍚岄€氳鍙戣〃棰樹负Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma鐨勭爺绌惰鏂囷紝璇ョ爺绌朵娇鐢ㄨ泲鐧借川缁勫鍜岀7閰歌泲......
TAG鏍囩锛?Nature 璐虹鍒濊棰樼粍 鑲濈檶娌荤枟 闈剁偣

鍦?019骞?鏈?7鏃ワ紝鍚屾椂鏈?绡嘚ature鏂囩珷鏄湁涓浗瀛﹁€?鍗庝汉鍙戣〃鐨勶紝鍏蜂綋鐨勬垚鏋滃涓嬮潰鎵€浠嬬粛锛?/p>

鍖椾含鐢熷懡缁勫鐮旂┒鎵€璐虹鍒濓紝澶嶆棪澶у闄勫睘涓北鍖婚櫌妯婂槈锛屽浗瀹惰泲鐧借川绉戝涓績閽卞皬绾㈠叡鍚岄€氳鍙戣〃棰樹负“Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma”鐨勭爺绌惰鏂囷紝璇ョ爺绌朵娇鐢ㄨ泲鐧借川缁勫鍜岀7閰歌泲鐧借川缁勫鍒嗘瀽锛屽彂鐜?10涓笌涔欏瀷鑲濈値鐥呮瘨鎰熸煋鐩稿叧鐨勪复搴婃棭鏈熻倽缁嗚優鐧岀殑鎴愬鑲跨槫鍜岄潪鑲跨槫缁勭粐銆傚畾閲忚泲鐧借川缁勫鏁版嵁绐佸嚭浜嗘棭鏈熻倽缁嗚優鐧岀殑寮傝川鎬э細鐮旂┒浜哄憳浣跨敤瀹冩潵灏嗚闃熷垪鍒嗗眰涓轰簹鍨婼-I锛孲-II鍜孲-III锛屾瘡绉嶄簹鍨嬪叿鏈変笉鍚岀殑涓村簥缁撴灉銆傛湰鐮旂┒涓彁鍑虹殑鏃╂湡鑲濈粏鑳炵檶鐨勮泲鐧借川缁勫鍒嗗眰锛屾彁渚涗簡瀵硅鐧岀棁鐨勮偪鐦ょ敓鐗╁鐨勬繁鍏ヤ簡瑙o紝骞舵彁鍑轰簡閽堝瀹冪殑涓€у寲娌荤枟鐨勬満浼氾紱

绗笁鍐涘尰澶у锛堥檰鍐涘尰绉戝ぇ瀛︼級鍗炰慨姝︼紝鍒樻柊涓滃強娓呭崕澶у钁f櫒绛変汉鍏卞悓閫氳鍙戣〃棰樹负“Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction”鐨勭爺绌惰鏂囷紝璇ヨ鏂囦娇鐢ㄥ皬榧犱綋澶朤缁嗚優鑰愬彈璇卞绯荤粺锛岀爺绌朵汉鍛樺彂鐜拌€愬彈鎬缁嗚優涓殑鍏ㄥ熀鍥犵粍琛ㄨ閬椾紶鍜屽熀鍥犺〃杈剧壒寰侊紝骞惰〃鏄庡畠浠笉鍚屼簬鏁堝簲鍜岃皟鑺傛€缁嗚優銆傚€煎緱娉ㄦ剰鐨勬槸锛岃浆褰曞洜瀛怤R4A1鍦ㄨ€愬彈鎬缁嗚優涓互楂樻按骞崇ǔ瀹氳〃杈俱€?NR4A1鐨勮繃琛ㄨ揪鎶戝埗鏁堝簲T缁嗚優鍒嗗寲锛岃€孨R4A1鐨勭己澶卞厠鏈嶄簡T缁嗚優鑰愬彈鎬у苟澶稿ぇ浜嗘晥搴斿姛鑳斤紝浠ュ強澧炲己瀵硅偪鐦ゅ拰鎱㈡€х梾姣掔殑鍏嶇柅鍔涖€傝鐮旂┒灏哊R4A1閴村畾涓鸿瀵糡缁嗚優鍔熻兘闅滅鐨勫叧閿竴鑸皟鑺傚洜瀛愶紝骞朵笖鏄偪鐦ゅ厤鐤枟娉曠殑娼滃湪闈舵爣锛?/p>

搴锋秴鐙勬牸澶у&娓╁窞鍖荤澶у&鍗庝腑鍐滀笟澶у闃竴楠忓洟闃熷彂琛?ldquo;Multiplex chromatin interactions with single-moleculeprecision”锛屾弿杩颁簡涓€绉嶅閲嶆煋鑹茶川鐩镐簰浣滅敤鍒嗘瀽鐨勭瓥鐣ワ紝绉颁箣涓篊hIA-Drop锛涜瘉鏄庝簡ChIA-Drop鍦ㄦ崟鎹夊鏉傜殑鏌撹壊璐ㄧ浉浜掍綔鐢ㄧ殑鍗曞垎瀛愮簿纭€э紝杩欐槸涓嶅彲鑳藉熀浜庣兢浣撴按骞充袱涓ゆ帴瑙︾殑鏂规硶娴嬪畾銆傚湪鏋滆潎涓彂鐜帮紝鏌撹壊璐ㄧ殑鎷撴墤缁撴瀯涓昏鐢卞叿鏈夐珮搴﹀紓璐ㄦ€х殑澶氶噸鏌撹壊璐ㄧ浉浜掍綔鐢ㄧ粍鎴愶紱ChIA-Drop杩樻彮绀轰簡浠ュ惎鍔ㄥ瓙涓轰腑蹇冪殑澶氫环鐩镐簰浣滅敤锛屼粠鑰屾彁渚涗簡瀵硅浆褰曠殑鎷撴墤瑙傚療锛?/p>

鍒掗噸鐐癸細3绡嘚ature鑳岄潬鑳?/strong>

涓浗绉戝闄㈢墿鐞嗙爺绌舵墍鏂硅景锛岀縼绾㈡槑鍏卞悓閫氳鍙戣〃棰樹负“Catalogue of topological electronic materials”鐨勭爺绌惰鏂囷紝璇ヨ鏂囦粙缁嶄簡涓€绉嶆湁鏁堬紝楂樻晥鍜屽叏鑷姩鐨勭畻娉曪紝鍙互璇婃柇澶ч儴鍒嗛潪纾佹€ф潗鏂欎腑鐨勯潪骞冲嚒甯︽嫇鎵戙€傝鐮旂┒鐨勭畻娉曟槸鍩轰簬鏈€杩戝紑鍙戠殑鍗犵敤甯︾殑瀵圭О琛ㄧず鍜屾嫇鎵戜笉鍙橀噺涔嬮棿鐨勭┓涓炬槧灏勩€傜爺绌朵汉鍛樺湪姘存櫠鏁版嵁搴撲腑鎵弿浜嗘€诲叡39,519绉嶆潗鏂欙紝鍙戠幇鍏朵腑澶氳揪8056绉嶆潗鏂欏湪鎷撴墤涓婇潪甯搁噸瑕併€傛墍鏈夌粨鏋滃潎鍙湪鍏锋湁浜や簰寮忕敤鎴风晫闈㈢殑鏁版嵁搴撲腑鎼滅储锛?/p>

鍗椾含澶уWan Xiaogang鍙戣〃棰樹负”Comprehensive search for topological materials using symmetry indicators“鐨勭爺绌惰鏂囷紝璇ヨ鏂囧皢瀵圭О鎸囩ず鍣ㄧ殑鏂规硶搴旂敤浜庢墍鏈?30涓彲鑳界┖闂寸兢涓殑鎵€鏈夊悎閫傜殑闈炵鎬у寲鍚堢墿銆傛暟鎹簱鎼滅储鏄剧ず浜嗘暟浠ュ崈璁$殑鍊欓€夋嫇鎵戞潗鏂欙紝鍏朵腑鐮旂┒浜哄憳绐佸嚭浜?41涓嫇鎵戠粷缂樹綋鍜?42涓嫇鎵戠粨鏅剁粷缂樹綋锛岃繖浜涚粷缂樹綋鍏锋湁鏄庢樉鐨勫叏甯﹂殭鎴栫浉褰撳ぇ鐨勭洿鎺ラ棿闅欎互鍙婂皬鐨勭悙纰庤垂绫冲彛琚嬨€傛澶栵紝鐮旂┒浜哄憳鍒楀嚭浜?92涓叿鏈変綅浜庤垂绫虫按骞抽檮杩戠殑甯︿氦鍙夌偣鐨勬嫇鎵戝崐閲戝睘銆傝繖浜涘€欓€夋潗鏂欏紑杈熶簡鍦ㄤ笅涓€浠g數瀛愯澶囦腑浣跨敤鎷撴墤鏉愭枡鐨勫彲鑳芥€э紱

鏅灄鏂】澶у/涓闄㈢墿鐞嗙爺绌舵墍鐜嬪織鍐涳紙闊宠瘧锛學ang Zhijun锛夊強鏅灄鏂】澶уB. Andrei Bernevig鍏卞悓閫氳鍙戣〃棰樹负”A complete catalogue of high-quality topological materials“鐨勭爺绌惰鏂囷紝璇ョ爺绌跺紑鍙戜唬鐮佹潵璁$畻26,938涓寲瀛﹁閲忔潗鏂欑殑鎵€鏈夊绉版€х殑鎵€鏈夌壒寰侊紝骞舵壘鍒?,307涓嫇鎵戠粷缂樹綋锛?,078涓嫇鎵戝崐閲戝睘涓旀病鏈夎剢寮辩浉銆?瀵逛簬杩?,385绉嶆潗鏂欙紝鐮旂┒浜哄憳鎻愪緵鐢靛瓙鑳藉甫缁撴瀯锛屽寘鎷竴浜涚數瀛愮壒鎬э紙甯﹂殭鍜岀數瀛愭暟锛夛紝瀵圭О鎬ф寚鏍囧拰鍏朵粬鎷撴墤淇℃伅銆?鐮旂┒缁撴灉琛ㄦ槑锛岃嚜鐒剁晫涓秴杩?7锛呯殑鏉愭枡鏄嫇鎵戝鐨勩€?璇ョ爺绌舵彁渚涗簡涓€涓紑婧愪唬鐮侊紝鐢ㄤ簬妫€鏌ヤ换浣曟潗鏂欑殑鎷撴墤缁撴瀯锛屽苟鍏佽鍏朵粬鐮旂┒浜哄憳閲嶇幇璇ョ爺绌剁殑缁撴灉锛?/p>

鍒掗噸鐐癸細3绡嘚ature鑳岄潬鑳?/strong>

鍔犲窞澶у浼厠鍒╁垎鏍$帇鏋洟闃熷彂琛ㄩ涓?ldquo;Observation of moiré excitons in WSe2/WS2 heterostructure superlattices”鐨勭爺绌惰鏂囷紝璇ヨ鏂囨姤鍛婁簡鍦ㄤ簩纭掑寲閽?浜岀~鍖栭挩锛圵Se2 / WS2锛夊紓璐ㄧ粨鏋勪腑鐨勮帿灏旇秴鏅舵牸婵€瀛愭€佺殑瑙傚療锛屽叾涓眰绱у瘑鎺掑垪銆傝帿灏旀縺瀛愬甫鎻愪緵浜嗕竴涓湁鍚稿紩鍔涚殑骞冲彴锛屽彲浠ヤ粠涓帰绱㈠拰鎺у埗鐗╄川鐨勬縺鍙戞€侊紝渚嬪鍦ㄨ繃娓¢噾灞炰簩纭寲鐗╀腑锛屾嫇鎵戞縺瀛愬拰鐩稿叧鐨勬縺瀛愬搱浼痉妯″瀷銆?/p>

鍗庣洓椤垮ぇ瀛u Xiaodong/棣欐腐澶уWang Yao鍙戣〃棰樹负“Signatures of moiré-trapped valley excitons in MoSe2/WSe2 heterobilayers”鐨勭爺绌惰鏂囷紝璇ョ爺绌舵姤鍛婁簡鍦ㄤ簩纭掑寲閽硷紙MoSe2锛?浜岀鍖栭挩锛圵Se2锛夊紓璐ㄥ眰涓崟鑾疯帿灏斿娍鐨勫眰闂磋胺婵€瀛愮殑瀹為獙璇佹嵁銆傝繖浜涚粨鏋滆〃鏄庤瀵熷埌鐨勬晥搴旂殑璧锋簮鏄眰闂存縺瀛愯鎹曡幏鍦ㄥ厜婊戠殑鑾皵鍔夸腑锛屽叿鏈夌户鎵跨殑璋峰姣旂墿鐞嗗銆傝繖椤瑰伐浣滄彁渚涗簡閫氳繃鏀瑰彉鎵浆瑙掓潵鎺у埗浜岀淮鑾皵鍏夊鐨勬満浼氥€?/p>

寰峰厠钀ㄦ柉澶у濂ユ柉姹€鍒嗘牎Li Xiaoqing/闃胯础鍥藉瀹為獙瀹u Fengcheng鍙戣〃棰樹负“Evidence for moiré excitons in van der Waals heterostructures”鐨勭爺绌惰鏂囷紝璇ョ爺绌舵姤鍛婁簡鍦ㄥ叿鏈夊皬鎵浆瑙掔殑浜岀鍖栭捈/浜岀鍖栭挩锛圡oSe2 / WSe2锛夊紓鍙屽眰涓殑姝f垨璐熷渾鏋佸寲鍙戝皠鐨勫涓眰闂存縺瀛愬叡鎸殑瑙傚療銆?杩欎簺缁撴灉琛ㄦ槑浣跨敤鑼冨痉鐡﹀皵鏂紓璐ㄧ粨鏋勮璁′汉宸ユ縺瀛愭櫠浣撶敤浜庣撼绫冲厜瀛愬鍜岄噺瀛愪俊鎭簲鐢ㄧ殑鍙鎬с€?/p>

1.鍖椾含鐢熷懡缁勫鐮旂┒鎵€璐虹鍒濓紝澶嶆棪澶у闄勫睘涓北鍖婚櫌妯婂槈锛屽浗瀹惰泲鐧借川绉戝涓績閽卞皬绾娇鐢ㄨ泲鐧借川缁勫纭畾浜嗘棭鏈熻倽缁嗚優鐧岀殑鏂版不鐤楅澏鐐?/strong>

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

鑲濈粏鑳炵檶鏄叏鐞冪檶鐥囨浜$殑绗笁澶у師鍥犮€傛劅鏌撲箼鍨嬭倽鐐庣梾姣掓槸鍙戝睍鑲濈粏鑳炵檶鐨勪富瑕佸嵄闄╁洜绱犱箣涓€锛岀壒鍒槸鍦ㄤ笢浜氬湴鍖恒€傝櫧鐒舵墜鏈不鐤楀彲鑳藉湪鏃╂湡闃舵鏈夋晥锛屼絾鍙戠敓杩欑鐧岀棁鍚庣殑浜斿勾鎬荤敓瀛樼巼浠呬负50-70锛呫€?/p>

鍦ㄨ繖閲岋紝鐮旂┒浜哄憳浣跨敤铔嬬櫧璐ㄧ粍瀛﹀拰纾烽吀铔嬬櫧璐ㄧ粍瀛﹀垎鏋愶紝鍙戠幇110涓笌涔欏瀷鑲濈値鐥呮瘨鎰熸煋鐩稿叧鐨勪复搴婃棭鏈熻倽缁嗚優鐧岀殑鎴愬鑲跨槫鍜岄潪鑲跨槫缁勭粐銆傚畾閲忚泲鐧借川缁勫鏁版嵁绐佸嚭浜嗘棭鏈熻倽缁嗚優鐧岀殑寮傝川鎬э細鐮旂┒浜哄憳浣跨敤瀹冩潵灏嗚闃熷垪鍒嗗眰涓轰簹鍨婼-I锛孲-II鍜孲-III锛屾瘡绉嶄簹鍨嬪叿鏈変笉鍚岀殑涓村簥缁撴灉銆?/p>

S-III鐨勭壒鐐规槸鑳嗗浐閱囩ǔ鎬佸彈鎹燂紝涓庝竴绾挎墜鏈悗鏈€浣庣殑鎬荤敓瀛樼巼鍜岄鍚庝笉鑹殑椋庨櫓鏈€澶ф湁鍏炽€傛暡闄ょ斁閱嘜-閰板熀杞Щ閰?锛圫OAT1锛? -鍏堕珮琛ㄨ揪鏄疭-III浜氬瀷鐗瑰紓鎬х殑鐗瑰緛  -鏀瑰彉缁嗚優鑳嗗浐閱囩殑鍒嗗竷锛屽苟鏈夋晥鎶戝埗鑲濈粏鑳炵檶鐨勫娈栧拰杩佺Щ銆傛渶鍚庯紝鍩轰簬鎮h€呮潵婧愮殑鑲濈粏鑳炵檶鑲跨槫寮傜绉绘灏忛紶妯″瀷锛岀爺绌朵汉鍛樺彂鐜扮敤SOAS1鎶戝埗鍓俛vasimibe娌荤枟鏄捐憲鍑忓皯浜嗗叿鏈夐珮姘村钩SOAT1琛ㄨ揪鐨勮偪鐦ょ殑澶у皬銆傛湰鐮旂┒涓彁鍑虹殑鏃╂湡鑲濈粏鑳炵檶鐨勮泲鐧借川缁勫鍒嗗眰锛屾彁渚涗簡瀵硅鐧岀棁鐨勮偪鐦ょ敓鐗╁鐨勬繁鍏ヤ簡瑙o紝骞舵彁鍑轰簡閽堝瀹冪殑涓€у寲娌荤枟鐨勬満浼氥€?/p>

鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41586-019-0987-8

2.绗笁鍐涘尰澶у锛堥檰鍐涘尰绉戝ぇ瀛︼級鍗炰慨姝︼紝鍒樻柊涓滃強娓呭崕澶у钁f櫒绛変汉浣跨敤鍏ㄥ熀鍥犵粍鍒嗘瀽灏哊R4A1閴村畾涓篢缁嗚優鍔熻兘闅滅鐨勫叧閿粙璐?/strong>

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

褰揟缁嗚優閬囧埌鑷韩鎶楀師鎴栨毚闇蹭簬鎱㈡€ф劅鏌撴垨鑲跨槫寰幆澧冩椂锛孴缁嗚優鍔熻兘浼氬け璋冦€?T缁嗚優鐨勫姛鑳藉彈缁勫悎鍏卞埡婵€淇″彿鐨勪弗鏍艰皟鑺傦紝璐熷叡鍒烘縺鐨勪紭鍔垮鑷碩缁嗚優鍔熻兘闅滅銆傜劧鑰岋紝杩欑鍔熻兘闅滅鐨勫垎瀛愭満鍒朵粛涓嶆竻妤氥€?/p>

鍦ㄨ繖閲岋紝浣跨敤灏忛紶浣撳T缁嗚優鑰愬彈璇卞绯荤粺锛岀爺绌朵汉鍛樺彂鐜拌€愬彈鎬缁嗚優涓殑鍏ㄥ熀鍥犵粍琛ㄨ閬椾紶鍜屽熀鍥犺〃杈剧壒寰侊紝骞惰〃鏄庡畠浠笉鍚屼簬鏁堝簲鍜岃皟鑺傛€缁嗚優銆傚€煎緱娉ㄦ剰鐨勬槸锛岃浆褰曞洜瀛怤R4A1鍦ㄨ€愬彈鎬缁嗚優涓互楂樻按骞崇ǔ瀹氳〃杈俱€?NR4A1鐨勮繃琛ㄨ揪鎶戝埗鏁堝簲T缁嗚優鍒嗗寲锛岃€孨R4A1鐨勭己澶卞厠鏈嶄簡T缁嗚優鑰愬彈鎬у苟澶稿ぇ浜嗘晥搴斿姛鑳斤紝浠ュ強澧炲己瀵硅偪鐦ゅ拰鎱㈡€х梾姣掔殑鍏嶇柅鍔涖€?/p>

鍦ㄦ満鍒朵笂锛孨R4A1浼樺厛鍕熼泦鍒拌浆褰曞洜瀛怉P-1鐨勭粨鍚堜綅鐐癸紝鍏朵腑瀹冮€氳繃鎶戝埗AP-1鍔熻兘鏉ユ姂鍒舵晥搴斿熀鍥犺〃杈俱€?NR4A1缁撳悎杩樹績杩涚粍铔嬬櫧3鍦ㄨ禆姘ㄩ吀27鐨勪箼閰板寲锛圚3K27ac锛夛紝瀵艰嚧鑰愬彈鐩稿叧鍩哄洜鐨勬縺娲汇€傚洜姝わ紝璇ョ爺绌跺皢NR4A1閴村畾涓鸿瀵糡缁嗚優鍔熻兘闅滅鐨勫叧閿竴鑸皟鑺傚洜瀛愶紝骞朵笖鏄偪鐦ゅ厤鐤枟娉曠殑娼滃湪闈舵爣銆?/p>

鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41586-019-0979-8

3.搴锋秴鐙勬牸澶у&娓╁窞鍖荤澶у&鍗庝腑鍐滀笟澶у闃竴楠忎娇鐢–hIA-Drop鎶€鏈紝鎹曡幏鍗曞垎瀛愭按骞崇殑澶氶噸鏌撹壊浣撲簰浣?/strong>

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

鐮旂┒浜哄憳閫氳繃灏哛NAPII鏌撹壊璐ㄥ厤鐤叡娌夋穩鍔犲埌ChIA-Drop涓紝鐮旂┒浜嗚浆褰曡皟鎺ц繃绋嬩腑鐨勫閲嶆煋鑹茶川鐩镐簰浣滅敤銆傜敤RNAPII-ChIA-Drop娉曢壌瀹氫簡S2缁嗚優涓害200涓囩鏌撹壊璐ㄥ鍚堢墿銆備竴鑸€岃█锛孯NAPII ChIA-Drop 鎷撴墤缁撴瀯绫讳技浜嶤HIA-DROP鎵€鎻ず鐨勬嫇鎵戠粨鏋勶紝浣嗘濡傞鏈熺殑閭f牱锛孯NAPII ChIA-Drop 缁撴瀯鍦ㄦ姂鍒跺煙(鍗砊ADS)鍜屾椿璺冨尯鍩?杈圭晫闂撮殭)涓〃鐜板嚭鏄庢樉鐨勪俊鍙峰噺灏戙€?/p>

鎬讳箣锛孋hIA-Drop鏄竴绉嶅湪鍗曞垎瀛愭按骞充笂鎹曟崏澶氶噸鏌撹壊璐ㄧ浉浜掍綔鐢ㄧ殑绠€鍗曘€佸彲闈犲拰鏈夋晥鐨勬柟娉曪紝涓庝互寰€鐨勫弻绉嶇兢姘村钩鏂规硶(濡侶i-C鍜孋hIA-Drop)涓嶅悓锛岃鏂规硶鍙渶5×103缁嗚優鎴?×104鐢ㄤ簬ChIP瀹為獙銆傚苟涓旓紝鐮旂┒浜哄憳鎻忚堪浜嗚浆褰曞閲嶇浉浜掍綔鐢ㄣ€備笌浠ュ墠鐨勭兢浣撴按骞冲垎鏋愮浉鍙嶏紝杩欑鍒嗘瀽鏆楃ず浜嗗箍娉涚殑鍚姩瀛?鍚姩瀛愮浉浜掍綔鐢ㄣ€俁NAPII ChIA-Drop鏁版嵁鏄剧ず锛?0%鐨勮浆褰曟椿鎬ф煋鑹茶川澶嶅悎鐗╁彧娑夊強涓€涓惎鍔ㄥ瓙涓庨潪鍚姩瀛愯繙绔厓绱犵殑鐩镐簰浣滅敤锛屽叾浣?0%鐨勬煋鑹茶川澶嶅悎鐗╂秹鍙婂涓惎鍔ㄥ瓙銆傚洜姝わ紝鐮旂┒浜哄憳鎻愬嚭浜嗕竴涓互鍚姩瀛愪负涓績鐨勬ā鍨嬶紝鐢ㄤ簬RNAP鈪′粙瀵肩殑杞綍銆?/p>

鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41586-019-0949-1

4.涓浗绉戝闄㈢墿鐞嗙爺绌舵墍鏂硅景锛岀縼绾㈡槑寮€鍙戠數瀛愭嫇鎵戞潗鏂欑洰褰?/strong>

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

璇稿纭掑寲閾嬶紝鐮峰寲閽藉拰閾嬮挔绛夋嫇鎵戠數瀛愭潗鏂欏湪浣撳唴鏄剧ず鍑洪潪甯歌鐨勭嚎鎬у搷搴旓紝浠ュ強鍦ㄥ叾杈圭晫澶勭殑寮傚父鏃犻棿闅欑姸鎬併€傚畠浠叿鏈夊熀鏈拰搴旂敤鐨勬剰涔夛紝鍏锋湁鍦ㄩ珮鎬ц兘鐢靛瓙鍜岄噺瀛愯绠椾腑浣跨敤鐨勬綔鍔涖€備絾鍒扮洰鍓嶄负姝紝瀹冧滑鐨勬娴嬪彈鍒拌绠楁嫇鎵戜笉鍙樼壒鎬э紙鎴栨嫇鎵戣妭鐐癸級鐨勫洶闅剧殑闃荤锛岃繖闇€瑕佸叿鏈夋潗鏂欏拰涓撲笟鐭ヨ瘑鐨勭粡楠屼互鍙婂厛杩涚殑鐞嗚宸ュ叿銆?/p>

鍦ㄨ繖閲岋紝鐮旂┒浜哄憳浠嬬粛浜嗕竴绉嶆湁鏁堬紝楂樻晥鍜屽叏鑷姩鐨勭畻娉曪紝鍙互璇婃柇澶ч儴鍒嗛潪纾佹€ф潗鏂欎腑鐨勯潪骞冲嚒甯︽嫇鎵戙€傝鐮旂┒鐨勭畻娉曟槸鍩轰簬鏈€杩戝紑鍙戠殑鍗犵敤甯︾殑瀵圭О琛ㄧず鍜屾嫇鎵戜笉鍙橀噺涔嬮棿鐨勭┓涓炬槧灏勩€傜爺绌朵汉鍛樺湪姘存櫠鏁版嵁搴撲腑鎵弿浜嗘€诲叡39,519绉嶆潗鏂欙紝鍙戠幇鍏朵腑澶氳揪8056绉嶆潗鏂欏湪鎷撴墤涓婇潪甯搁噸瑕併€傛墍鏈夌粨鏋滃潎鍙湪鍏锋湁浜や簰寮忕敤鎴风晫闈㈢殑鏁版嵁搴撲腑鎼滅储銆?/p>

鎬讳箣锛岀爺绌跺己璋冭繖绉嶆帓鍚嶅彧搴旇瑙嗕负鍙傝€冿紝鍚屾椂鐮旂┒浜哄憳寤鸿瀵圭壒瀹氬€欓€夋潗鏂欐劅鍏磋叮鐨勮鑰呭簲璇ヤ粩缁嗘鏌ュ湪绾挎暟鎹簱涓樉绀虹殑鐩稿叧缁撴瀯銆?/p>

鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41586-019-0944-6

5.鍗椾含澶уWan Xiaogang浣跨敤瀵圭О鎸囨爣鍏ㄩ潰鎼滅储鎷撴墤鏉愭枡

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

鍦ㄨ繃鍘荤殑鍗佸勾涓紝鎷撴墤鏉愭枡  -鍏朵腑鏁h鏉愭枡涓殑鐢靛瓙甯︽嫇鎵戠粨鏋勫鑷村己澶х殑锛岄潪甯歌鐨勮〃闈㈢姸鎬佸拰鐢电  -寮曡捣浜嗗緢澶氬叧娉ㄣ€傚敖绠″凡缁忛€氳繃瀹為獙璇佸疄浜嗗嚑绉嶇悊璁轰笂鎻愬嚭鐨勬嫇鎵戞潗鏂欙紝浣嗘嫇鎵戞€ц川鐨勫箍娉涘疄楠屾帰绱互鍙婂湪鐜板疄瑁呯疆涓殑搴旂敤锛屽彈鍒扮己涔忔嫇鎵戞潗鏂欑殑闄愬埗锛屽叾涓潵鑷钩鍑¤垂绫宠〃闈㈡€佺殑骞叉壈琚渶灏忓寲銆?/p>

鍦ㄨ繖閲岋紝鐮旂┒浜哄憳灏嗗绉版寚绀哄櫒鐨勬柟娉曞簲鐢ㄤ簬鎵€鏈?30涓彲鑳界┖闂寸兢涓殑鎵€鏈夊悎閫傜殑闈炵鎬у寲鍚堢墿銆傛暟鎹簱鎼滅储鏄剧ず浜嗘暟浠ュ崈璁$殑鍊欓€夋嫇鎵戞潗鏂欙紝鍏朵腑鐮旂┒浜哄憳绐佸嚭浜?41涓嫇鎵戠粷缂樹綋鍜?42涓嫇鎵戠粨鏅剁粷缂樹綋锛岃繖浜涚粷缂樹綋鍏锋湁鏄庢樉鐨勫叏甯﹂殭鎴栫浉褰撳ぇ鐨勭洿鎺ラ棿闅欎互鍙婂皬鐨勭悙纰庤垂绫冲彛琚嬨€傛澶栵紝鐮旂┒浜哄憳鍒楀嚭浜?92涓叿鏈変綅浜庤垂绫虫按骞抽檮杩戠殑甯︿氦鍙夌偣鐨勬嫇鎵戝崐閲戝睘銆傝繖浜涘€欓€夋潗鏂欏紑杈熶簡鍦ㄤ笅涓€浠g數瀛愯澶囦腑浣跨敤鎷撴墤鏉愭枡鐨勫彲鑳芥€с€?/p>

鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41586-019-0937-5

6.鏅灄鏂】澶у/涓闄㈢墿鐞嗙爺绌舵墍鐜嬪織鍐涳紙闊宠瘧锛學ang ZhiJun锛夊強鏅灄鏂】澶уB. Andrei Bernevig寮€鍙戠數瀛愭嫇鎵戞潗鏂欑洰褰?/strong>

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

浣跨敤鏈€杩戝紑鍙戠殑绉颁负鎷撴墤閲忓瓙鍖栧鐨勫舰寮忎富涔夛紝鐮旂┒浜哄憳鍦ㄦ棤鏈烘櫠浣撶粨鏋勬暟鎹簱涓“楂樿川閲?rdquo;鏉愭枡锛堝叾涓師瀛愪綅缃拰缁撴瀯宸茬粡闈炲父绮剧‘鍦版祴閲忥級杩涜楂橀€氶噺鎼滅储锛屼互渚胯瘑鍒柊鎷撴墤闃舵銆?/p>

鐮旂┒浜哄憳寮€鍙戜唬鐮佹潵璁$畻26,938涓寲瀛﹁閲忔潗鏂欑殑鎵€鏈夊绉版€х殑鎵€鏈夌壒寰侊紝骞舵壘鍒?,307涓嫇鎵戠粷缂樹綋锛?,078涓嫇鎵戝崐閲戝睘涓旀病鏈夎剢寮辩浉銆?瀵逛簬杩?,385绉嶆潗鏂欙紝鐮旂┒浜哄憳鎻愪緵鐢靛瓙鑳藉甫缁撴瀯锛屽寘鎷竴浜涚數瀛愮壒鎬э紙甯﹂殭鍜岀數瀛愭暟锛夛紝瀵圭О鎬ф寚鏍囧拰鍏朵粬鎷撴墤淇℃伅銆?鐮旂┒缁撴灉琛ㄦ槑锛岃嚜鐒剁晫涓秴杩?7锛呯殑鏉愭枡鏄嫇鎵戝鐨勩€?璇ョ爺绌舵彁渚涗簡涓€涓紑婧愪唬鐮侊紝鐢ㄤ簬妫€鏌ヤ换浣曟潗鏂欑殑鎷撴墤缁撴瀯锛屽苟鍏佽鍏朵粬鐮旂┒浜哄憳閲嶇幇璇ョ爺绌剁殑缁撴灉銆?/p>

鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41586-019-0954-4

7,8,9.鍔犲窞澶у浼厠鍒╁垎鏍$帇鏋紝鍗庣洓椤垮ぇ瀛u Xiaodong/棣欐腐澶уWang Yao锛屽痉鍏嬭惃鏂ぇ瀛﹀ゥ鏂眬鍒嗘牎Li Xiaoqing/闃胯础鍥藉瀹為獙瀹u Fengcheng鍚屾椂鍙戣〃3绡囨枃绔狅紝鍦ㄦ潗鏂欏棰嗗煙鍙栧緱鏂拌繘灞?/strong>

9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=
9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=
9绡嘚ature鏂囩珷鍚屾椂鍙戣〃 璐虹鍒濊棰樼粍鍙戠幇鑲濈檶娌荤枟鏂伴澏鐐? onclick=

鑾皵瓒呮櫠鏍艰兘澶熷湪浜岀淮寮傝川缁撴瀯涓骇鐢熸柊鐨勯噺瀛愮幇璞★紝鍏朵腑鍘熷瓙钖勫眰涔嬮棿鐨勭浉浜掍綔鐢ㄥ畾鎬у湴鏀瑰彉瓒呮櫠鏍肩殑鐢靛瓙鑳藉甫缁撴瀯銆備緥濡傦紝mini-Dirac鐐癸紝鍙皟璋怣ott缁濈紭浣撶姸鎬佸拰Hofstadter铦跺舰鍥炬锛屽彲浠ュ嚭鐜板湪涓嶅悓绫诲瀷鐨勭煶澧ㄧ儻/姘寲纭艰帿灏旇秴鏅舵牸涓紝鑰岀浉鍏崇殑缁濈紭鐘舵€佸拰瓒呭鎬у凡缁忓湪鎵洸鐨勫弻灞傜煶澧ㄧ儻鑾皵瓒呮櫠鏍间腑鎶ラ亾銆傞櫎浜嗗畠浠鍗曠矑瀛愮姸鎬佺殑鏄捐憲褰卞搷涔嬪锛屾渶杩戣繕棰勬祴鑾皵瓒呮櫠鏍煎彲浠ュ瓨鍦ㄦ縺鍙戞€侊紝濡傝帿灏旀縺瀛愬甫銆?/p>

鍦ㄨ繖閲岋紝鍔犲窞澶у浼厠鍒╁垎鏍$帇鏋洟闃熸姤鍛婁簡鍦ㄤ簩纭掑寲閽?浜岀~鍖栭挩锛圵Se2 / WS2锛夊紓璐ㄧ粨鏋勪腑鐨勮帿灏旇秴鏅舵牸婵€瀛愭€佺殑瑙傚療锛屽叾涓眰绱у瘑鎺掑垪銆傝繖浜涜帿灏旀縺瀛愭€佽〃鐜颁负鍚告敹鍏夎氨涓師濮媁Se2 A婵€瀛愬叡鎸懆鍥寸殑澶氫釜鍑哄皠宄帮紝骞朵笖瀹冧滑琛ㄧ幇鍑轰笌WSe2鍗曞眰涓殑A婵€瀛愬拰鍏锋湁澶ф壄杞鐨刉Se2 / WS2寮傝川缁撴瀯涓嶅悓鐨勬爡鏋佷緷璧栨€с€傝繖浜涚幇璞″彲浠ラ€氳繃鐞嗚妯″瀷鏉ユ弿杩帮紝鍏朵腑鍛ㄦ湡鎬ц帿灏旂數鍔挎瘮婵€瀛愬姩鑳藉己寰楀锛屽苟浜х敓澶氫釜骞抽潰婵€瀛愬井甯︺€傝帿灏旀縺瀛愬甫鎻愪緵浜嗕竴涓湁鍚稿紩鍔涚殑骞冲彴锛屽彲浠ヤ粠涓帰绱㈠拰鎺у埗鐗╄川鐨勬縺鍙戞€侊紝渚嬪鍦ㄨ繃娓¢噾灞炰簩纭寲鐗╀腑锛屾嫇鎵戞縺瀛愬拰鐩稿叧鐨勬縺瀛愬搱浼痉妯″瀷銆?/p>

鍙﹀锛屽崕鐩涢】澶уXu Xiaodong/棣欐腐澶уWang Yao鎶ュ憡浜嗗湪浜岀鍖栭捈锛圡oSe2锛?浜岀鍖栭挩锛圵Se2锛夊紓璐ㄥ眰涓崟鑾疯帿灏斿娍鐨勫眰闂磋胺婵€瀛愮殑瀹為獙璇佹嵁銆傚湪浣庢俯涓嬶紝鐮旂┒浜哄憳瑙傚療鍒板厜鑷村彂鍏夋帴杩戣嚜鐢卞眰闂存縺瀛愯兘閲忥紝浣嗙嚎瀹借秴杩囦竴鐧惧€嶏紙绾?00寰數瀛愪紡鐗癸級銆傚彂灏勫櫒g鍥犲瓙鍦ㄥ悓涓€鏍峰搧涓槸鍧囧寑鐨勶紝骞朵笖鍦ㄥ垎鍒叿鏈?0搴﹀拰0搴︾殑杩戜技鎵浆瑙掔殑鏍峰搧涓粎鍙栦袱涓€硷紝-15.9鍜?.7銆傚浜庣粰瀹氱殑鎵浆瑙掞紝鍙戝皠鍣ㄨ〃鐜板嚭鐩稿悓铻烘棆鎬х殑寮哄渾鏋佸寲锛岃繖琛ㄦ槑淇樿幏鍔夸繚鎸佷笁閲嶆棆杞绉版€с€傜粨鍚堝鍔熺巼鍜屾縺鍙戣兘閲忕殑鐗瑰緛渚濊禆鎬э紝杩欎簺缁撴灉琛ㄦ槑瑙傚療鍒扮殑鏁堝簲鐨勮捣婧愭槸灞傞棿婵€瀛愯鎹曡幏鍦ㄥ厜婊戠殑鑾皵鍔夸腑锛屽叿鏈夌户鎵跨殑璋峰姣旂墿鐞嗗銆傝繖椤瑰伐浣滄彁渚涗簡閫氳繃鏀瑰彉鎵浆瑙掓潵鎺у埗浜岀淮鑾皵鍏夊鐨勬満浼氥€?/p>

鏈夎叮鐨勬槸锛屽痉鍏嬭惃鏂ぇ瀛﹀ゥ鏂眬鍒嗘牎Li Xiaoqing/闃胯础鍥藉瀹為獙瀹u Fengcheng鎶ュ憡浜嗗湪鍏锋湁灏忔壄杞鐨勪簩纭掑寲閽?浜岀鍖栭挩锛圡oSe2 / WSe2锛夊紓鍙屽眰涓殑姝f垨璐熷渾鏋佸寲鍙戝皠鐨勫涓眰闂存縺瀛愬叡鎸殑瑙傚療銆?鐮旂┒浜哄憳灏嗚繖浜涘叡鎸綊鍥犱簬婵€瀛愬熀鎬佸拰鍙楅檺浜庤帿灏斿娍鐨勬縺鍙戞€併€?杩欑瑙i噴寰楀埌浜嗛噸缁勫姩鍔涘浠ュ強杩欎簺灞傞棿婵€瀛愬叡鎸鎵浆瑙掑拰娓╁害鐨勪緷璧栨€х殑鏀寔銆?杩欎簺缁撴灉琛ㄦ槑浣跨敤鑼冨痉鐡﹀皵鏂紓璐ㄧ粨鏋勮璁′汉宸ユ縺瀛愭櫠浣撶敤浜庣撼绫冲厜瀛愬鍜岄噺瀛愪俊鎭簲鐢ㄧ殑鍙鎬с€?/p>

鏂囩珷鏉ユ簮锛歨ttp://mp.weixin.qq.com/s?__biz=MzU3MTE3MjUyOA==&mid=2247498949&idx=1&sn=b6e852da257f28608ab16c3ef45f6133&chksm=fce68f1acb91060ce43cc7f75d704d10cbb685cba0bf509c824ed13e5bc2d5d98ffbdc535a8e&mpshare=1&scene=1&srcid=#rd

锛堟湰鏂囨潵婧愶細iNature 锛?

(璐d换缂栬緫锛?榫欐櫙)

寮曠敤鍦板潃锛?a href="#" target=_blank>

TAG鏍囩锛?Nature 璐虹鍒濊棰樼粍 鑲濈檶娌荤枟 闈剁偣
椤朵竴涓?/div>
(0)
0%
韪╀竴涓?/div>
(0)
0%
鍏嶈矗澹版槑锛?/strong> 闄ゆ爣鏄庛€婂疄楠屽璧勮缃戙€嬪師鍒涘锛屾湰缃戦儴鍒嗘枃绔犺浆杞借嚜鍏跺畠濯掍綋锛岃浆杞界洰鐨勫湪浜庝紶閫掓洿澶氫俊鎭紝 骞朵笉浠h〃鏈綉璧炲悓鍏惰鐐瑰拰瀵瑰叾鐪熷疄鎬ц礋璐o紝涓斾笉鎵挎媴姝ょ被浣滃搧渚垫潈琛屼负鐨勭洿鎺ヨ矗浠诲強杩炲甫璐d换銆? 濡傚叾浠栧獟浣撱€佺綉绔欐垨涓汉浠庢湰缃戜笅杞戒娇鐢紝鑷礋鐗堟潈绛夋硶寰嬭矗浠汇€傚娑夊強浣滃搧鍐呭銆佺増鏉冨拰鍏跺畠闂锛? 璇峰湪30鏃ュ唴涓庢湰缃戣仈绯伙紝鎴戜滑灏嗗湪绗竴鏃堕棿鍒犻櫎鍐呭锛?
------鍒嗛殧绾?---------------------------
鍙戣〃璇勮
璇疯嚜瑙夐伒瀹堜簰鑱旂綉鐩稿叧鐨勬斂绛栨硶瑙勶紝涓ョ鍙戝竷鑹叉儏銆佹毚鍔涖€佸弽鍔ㄧ殑瑷€璁恒€?/small>
璇勪环:
琛ㄦ儏:
鏈€鏂拌瘎璁?/strong> 杩涘叆璇︾粏璇勮椤?gt;>
鎺ㄨ崘鍐呭